If there are not any potential interactions, then it is safe to consume citrus or grapefruit products as part of a healthy diet. It is important to discuss your medications with your doctor to determine if any of your medications could have this dangerous interaction. 'Grapefruit and grapefruit juice can interact with several medications, including those that treat conditions like high cholesterol and high blood pressure,' Goscilo says. Reducing your intake of these citrus products or simply choosing alternative fluids (including water) may be advisable to prevent such potentially dangerous side effects. The bottom line is that you should be careful when consuming citrus juice, especially grapefruit juice, if you require certain classes of medications (which have the potential for these serious reactions). If you’re taking an antidepressant, there are side effects and potential interactions to know about. Grapefruit juice also lowers levels of the medicine acebutolol, which is a beta-blocker used for high blood pressure, chest pain, and irregular heartbeat. In this way, there can be some medications that could be safer to take with grapefruit juice. Grapefruit and grapefruit juice interact with various medications. It is important to realize that the grapefruit interaction is specific to only certain medications within a drug class and not the entire class of drugs.
The toxic effect can potentially occur even if grapefruit is consumed many hours before taking the medication.Īs an example simvastatin taken daily with a 7 ounce glass of grapefruit juice, can result in up to a 330 percent higher concentration of drug in the body compared to taking it with water alone, potentially leading to a serious and and potentially life threatening complication called rhabdomyolysis which can lead to kidney failure. The degree of the grapefruit interaction is variable, with the potential for a toxic effect of a medication to occur from just one serving of grapefruit juice.
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